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KMID : 0043320110340081373
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Archives of Pharmacal Research
2011 Volume.34 No. 8 p.1373 ~ p.1380
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Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells
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Lee Hak-Ju
Lyu Da-Hyun
Koo Uk
Lee Sung-Jin
Hong Seong-Su
Kim Kem-Ok
Kim Kyeong-Ho
Lee Dong-Ho
Mar Woong-Chon
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Abstract
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Three known 2-arylbenzofurans, moracin P (1), moracin O (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1?3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC50 values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1?3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC50 values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner. Taken together, compounds 1?3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.
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KEYWORD
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Mori Cortex Radicis, Moraceae, 2-Arylbenzofurans, Oxygen-glucose deprivation, MTT, ROS
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